Hormone Replacement Success – Rhythmic Dosing versus Low-Dose Static Dosing

Lori is a 51 year old patient who first came to my office in April 2007 for bioidentical hormone replacement therapy. She was interested in traditional low-dose, static hormone replacement therapy so I started her on a combination of progesterone cream, estradiol/estriol (“Bi-est”) cream, testosterone cream, and Armour thyroid.

After starting this therapy she felt better, but still had a hot flash when going to bed and she also felt a little hot throughout the night.

Her sleep was better, but she still woke up once in the middle of the night.

Memory was not as much of a problem but she still had some problem with recall.

In December 2007, I recommended that she switch to using rhythmic bioidentical hormone replacement therapy, following the Wiley Protocol. She started using estradiol and progesterone at dosage levels that follow the pattern that we see in healthy young women.

Within several months after starting the Wiley Protocol she noticed the following improvements:

  • Improved hair
  • Improvement of vaginal dryness
  • Improved skin (less dry).
  • Complete resolution of hot flashes and night sweats
  • Improved sleep
  • Less irritability
  • Improved quality of hair (less thin)

I recommended increasing the dosage of estradiol.

When I saw her for a routine follow up today the patient reported the following improvements:

  • Good libido
  • Improved memory
  • Improved thickness of hair with a return of the natural waviness
  • Improved skin

As compared to using low-dose, static testosterone replacement, she felt that the rhythmic testosterone replacement caused her libido to be more natural. With the low-dose, static dosing regimen her libido was at times too aggressive and she also had more unwanted hair on her legs.

The patient had also been using the Wiley Protocol Face Creme which contains insulin, estradiol, and triiodothyronine (T3) and which helps rejuvenate the skin and fade fine lines and wrinkles. This worked very well for her. I have some patients who reported that this Creme works a lot better than some very expensive skin care products that they had purchased previously.

I now have about 200 patients that have started rhythmic, bioidentical hormone replacement therapy following the Wiley Protocol. It has been a very rewarding experience for me to see many regain their sense of well being and in many cases even regain their lives after restoring their hormones to optimal levels.