Bisphenol A and Genetic Studies

The study states that Bisphenol A acts like an estrogen and implies that estrogen is bad. I disagree with that. Both men and women make estrogens (estradiol and its main metabolites estriol and estrone). They are an essential part of the spectrum of steroid hormones that humans produce and we need optimal levels in our bodies for good health.

However, it appears that Bisphenol A is a hormone disrupting chemical that interferes with normal hormone physiology much like other environmental toxins such as those found in pesticides and other household or industrial chemicals.

From: FACT [mailto:moderator@gordonresearch.com]
Sent: Thursday, December 17, 2009 4:46 PM
Subject: Bisphenol A and genetic studies

Anyone reviewing the extensive research on Bisphenol A and the epigenetic changes in methylation Jirtle at Duke has documented will have no question that we need to realize that Bisphenol A is toxic no matter how many wish to try to deny this research. The changes induced in our EPIGENOME are permanent unless aggressive METHYLATION support is provided with nutrients such as 5′MTHF, B-12, TMG, and MSM, which I use for most patients daily.

Randy Jirtle’s study on Bisphenol A and EPIGENETIC changes leading to obesity and diabetes: http://www.pbs.org/wgbh/nova/genes/expert.html

The lies about Bisphenol A safety are going to have to be replaced by truth.  It is bad in low levels and even worse when its toxic effects are magnified by other toxins we all carry.

We need to bring the cost of measuring all toxins down and medicine will go through a total revolution where Detoxification becomes the first line of treatment.

Finally we see a study that looks at more than one toxin; here it’s estrogen exposure with BISPHENOL A. This combination led to a synergistic adverse effect on heart muscle cells causing abnormal heart beat. How many patients today are on some dangerous and expensive drugs for arrhythmias when treating causes makes sense?

Then what if you tried to study the combined toxic effect of a few toxins, like flame retardants (PBDE’s) that we find in everyone today know to be thyroid toxic, and then a little lead and mercury and some dioxins.  Finally we would know why everyone has so many health problems today. But the chemical society is incensed that anyone dares to do any of this research about their favorite chemicals to offer us better living through chemistry!

We all remember that birth control pills make smoking much more dangerous. So, of course, only by studying the adverse effects of more than one toxin at once will we find the true dangers we face. Medicine needs a new paradigm where first we look at toxins in our patients and consider removing all of them.

And, what if you put a healthy signal on that receptor first? We know that Longevity Plus offers the well-documented all natural SERM BETA product. No one going through menopause should be without H.R.T Plus (PURESTROL from Thailand). Remember this is a natural powerful S.E.R.M. beta (selective estrogen receptor modulator) of the beta receptor. This raises the possibility that Purestrol may help overcome the arrhythmia and help with another Bisphenol A related problem: premature puberty.

I have been feeling better and better with my total detox program, which has been greatly enhanced now with Zeolite Based Products available only from Longevity Plus.

Garry F. Gordon MD,DO,MD(H)

President, Gordon Research Institute

www.gordonresearch.com

http://www.foodproductiondaily.com/Quality-Safety/New-studies-link-BPA-to-heartbeat-and-fertility-problems

Breaking News on Food Processing & Packaging

New studies link BPA to heartbeat and fertility problems

By Rory Harrington, 11-Jun-2009

Fresh research linking bisphenol A (BPA) to heart beat disorders and fertility problems have added to the growing weight of opinion questioning the safety of the chemical.

BPA is used to make hard, clear plastics for food containers, dental sealants and the sealants that line food and beverage cans. Concern over the chemical has been rising in the US resulting in it being banned in two states and an announcement from the Food and Drug Administration to review its opinion that BPA is safe.

Two new studies presented this week at the Endocrine Society’s annual meeting in Washington are sure to add to the controversy surrounding the chemical.

Irregular heartbeat

A study by a team at the University of Cincinnati (UC) found that exposure to BPA and/or estrogen causes abnormal activity in the hearts of female rats and mice. The group, lead by associate professor of pharmacology Scott Belcher, said that estrogen receptors are responsible for this effect in heart muscle cells.

Belcher said: “There is broad exposure to bisphenol A, despite recognition that BPA can have harmful effects. We had reason to believe that harmful cardiovascular affects can be added to the list.”

The scientists said live cultures of cardiac cells isolated from rat or mouse hearts were briefly exposed to BPA and/or estrogen. It found the reaction in terms of heartbeat was sex-specific to women.

“Both compounds caused striking changes in the activity of cardiac muscle cells from females but not males,” said a UC statement. “Additional studies revealed that these cellular changes in activity caused improperly controlled beating in the female heart.”

Belcher added: “Basically, it’s very clear that BPA is acting like estrogen. If we give estrogen at physiological concentrations, then add BPA, it’s actually a synergistic effect. It’s not like adding the two together. It’s worse.”

A second study presented by Yale University School of Medicine’s reproductive endocrinology team claimed to show adverse effects on fertility in rodents following exposure to BPA.

Gene altering

The group, led by Professor Hugh Taylor, injected pregnant mice with a low dose of the chemical. After the animals gave birth, the scientists analyzed the uterus of female offspring and extracted DNA. They found that BPA contact during pregnancy had a lasting effect on one of the genes that is responsible for uterine development and subsequent fertility in both mice and humans (HOXA10).

“The genes that are necessary for normal pregnancy are altered,” said Taylor, adding BPA changed the DNA code and the ability of DNA to express these genes.

He said: “A little transient exposure during a brief time period in pregnancy could permanently alter the DNA of the uterus.

“We don’t know what a safe level of BPA is, so pregnant women should avoid BPA exposure. There is nothing to lose by avoiding items made with BPA—and maybe a lot to gain.”

Research techniques questioned

But the American Chemistry Council (ACC) rejected the validity of the studies, accusing the authors of “bypassing the scientific process in favor of sensational press releases” and as “a scare tactic that will not promote public health”.

Steven G. Hentges, of the ACC, said: “It is disappointing to see that some researchers continue to inject animals with bisphenol A since this experimental technique has recently been acknowledged by the National Institute of Environmental Health Sciences to have very limited value for assessing human health effects. In addition, studies on cell cultures are unlikely to be directly relevant to human health and, unless and until such relevance is scientifically validated, should not be presented as evidence of health risks.”

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