Hormone Replacement Success - Rhythmic Dosing versus Low-Dose Static Dosing

Lori is a 51 year old patient who first came to my office in April 2007 for bioidentical hormone replacement therapy. She was interested in traditional low-dose, static hormone replacement therapy so I started her on a combination of progesterone cream, estradiol/estriol (“Bi-est”) cream, testosterone cream, and Armour thyroid.

After starting this therapy she felt better, but still had a hot flash when going to bed and she also felt a little hot throughout the night.

Her sleep was better, but she still woke up once in the middle of the night.

Memory was not as much of a problem but she still had some problem with recall.

In December 2007, I recommended that she switch to using rhythmic bioidentical hormone replacement therapy, following the Wiley Protocol. She started using estradiol and progesterone at dosage levels that follow the pattern that we see in healthy young women.

Within several months after starting the Wiley Protocol she noticed the following improvements:

Improved hair
Improvement of vaginal dryness
Improved skin (less dry).
Complete resolution of hot flashes and night sweats
Improved sleep
Less irritability
Improved quality of hair (less thin)

I recommended increasing the dosage of estradiol.

When I saw her for a routine follow up today the patient reported the following improvements:

Good libido
Improved memory
Improved thickness of hair with a return of the natural waviness
Improved skin

As compared to using low-dose, static testosterone replacement, she felt that the rhythmic testosterone replacement caused her libido to be more natural. With the low-dose, static dosing regimen her libido was at times too aggressive and she also had more unwanted hair on her legs.

The patient had also been using the Wiley Protocol Face Creme which contains insulin, estradiol, and triiodothyronine (T3) and which helps rejuvenate the skin and fade fine lines and wrinkles. This worked very well for her. I have some patients who reported that this Creme works a lot better than some very expensive skin care products that they had purchased previously.

I now have about 200 patients that have started rhythmic, bioidentical hormone replacement therapy following the Wiley Protocol. It has been a very rewarding experience for me to see many regain their sense of well being and in many cases even regain their lives after restoring their hormones to optimal levels.

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Fred Bloem MD

August 12, 2009 at 2:54 am · Reply

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February 18, 2010 at 12:29 pm · Reply

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May 28, 2010 at 6:50 pm · Reply

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August 20, 2010 at 4:10 pm · Reply

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October 14, 2010 at 5:39 pm · Reply

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October 17, 2010 at 7:50 pm · Reply

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November 13, 2010 at 4:43 pm · Reply

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August 17, 2011 at 3:07 am · Reply

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October 15, 2011 at 12:59 am · Reply

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November 17, 2011 at 10:20 pm · Reply

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November 17, 2011 at 10:23 pm · Reply

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November 23, 2011 at 3:21 pm · Reply

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Dorothy Pugh

November 23, 2011 at 10:22 pm · Reply

This rotation of estrogen and progesterone is very interesting. I have a sneaking suspicion that the alternation of estrogen and progesterone dominance that premenopausal women experience keeps them from getting breast cancer unless they have problem BRCA genes or some other unusual situation. On the other hand, the chance of getting breast cancer rises steadily after menopause. Why is this so? Perhaps because some tumors have estrogen receptors and others progesterone receptors, so tumors are starved or destroyed when one hormone is cut off and another — an antagonist, in fact — takes its place. But postmenopausal women experience continuous estrogen dominance without intervention and get no protection from estrogen-dependent tumors. It's encouraging that this improved this patient's situation. I hope that clinical research will someday explore this further.

drbloem

November 23, 2011 at 11:16 pm · Reply

There are many potential causes and contributing factors with regard to the development of breast cancer, which may include prior use of oral/chemical contraceptives, vaccines, genetically modified foods, nutritionally deficient diets, electromagnetic fields, cell phones, ionizing radiation from mammograms and TSA body scanners, etcetera. However, I believe that all cells in the body have receptors for estrogens, progesterone and other hormones, which explains why they are all responsive to the effects of these hormones. I don't like the term "estrogen dominance" because it makes you believe the levels of estrogens are higher than the levels of progesterone. We know that in the postmenopausal period both estradiol and progesterone levels are low. That explains why when we restore hormone levels to youthful levels and when we restore the hormonal rhythm patients regain their sense of well being. Unfortunately, many doctors believe that bioidentical hormone replacement therapy should be avoided in women with "estrogen receptor positive" tumors even when there is no evidence whatsoever that it cancer is caused by estrogens. Why on earth would the body make hormones if they caused cancer?